New challenges for intelligent reconfigurable manufacturing systems are on the agenda for the next generation of machine tool centres. Zero defect workpieces and just-in-time production are some of the objectives to be reached for better quality and high performance production. Sustainability requires a holistic approach to cover not only flexible intelligent manufacture but also product and services activities. New routes philosophy of possible machine architecture with characteristics such as hybrid processes with in-process inspection and self-healing will be presented with great features as well as challenges related to various aspects of the next generation of intelligent machine tool centres.